YBS Biographer Newsletter
Autumn/Winter 2012 Join our mailing list and download the latest and previous copies of our quarterly newsletter.
> Latest Edition
Development, Validation and Application of a High Sensitivity On-line Extraction LC-MS/MS Method for the Determination of a Parent Molecule and its Metabolites M1 and M2 in Human Plasma
Authors:Mohammed Abrar, John Allanson, Hayley Hawthorne and Kevin Holmes
Presented / Published:Poster Presentation at Joint JPAG/DMDG Symposium: New approaches in bioanalysis and analytical technologies, London
Publication Date:16 May 2013

Publication Information:
The objective of this study was to validate the analytical method for the determination of a parent compound and its main metabolites (M1 and M2) in human plasma, over a concentration range of 0.1 to 20 pg/mL (parent) and 0.25 to 20 pg/mL (M1 and M2).  A sample aliquot volume of 500 µL was used.  This assay concentration range was required due to the high potency and hence low therapeutic doses of the parent compound administered.  The typical Cmax was expected to be in the low pg/mL levels.

DMDG 2013_Determination of a Parent Molecule and its Metabolites M1 and M2 in Human Plasma_V2.pdf

Back to Publications
Printer Friendly  |   Sitemap © Unilabs Bioanalytical Solutions 2010 - 2017  |   Privacy Policy  |   Website Disclaimer  |   Website Credits