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Metabolite Characterisation
An understanding of the metabolism of lead compounds and series has become a critical aspect of the drug discovery and development process. Metabolism or biotransformation studies may occur early in drug discovery, fulfilling the desire to impact drug design; in late development, providing key data for regulatory submissions; and anywhere throughout the discovery and development continuum, answering project-specific questions as they arise and contributing to a complete picture of a compound’s metabolic vulnerability, enzymology and safety.
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