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Determination of hydrophobic analytes in urine: Pitfalls and strategies
The solvent environment provided by urine may affect the solubility of analytes, resulting in partial and variable loss from solution on storage at reduced temperatures. This may present as apparently poor stability, or as very high variability, with observed concentrations significantly higher, or lower, than actual, according to the nature of the sample taken for analysis. The analytical results in either case are, therefore, questionable. In this presentation, two compounds which were adversely affected by urine solubility issues are highlighted, and alternative strategies for the resolution of the problems observed are given.
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