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Bioanalysis of labile compounds – Part 2
In the first part of this article (Biographer, Autumn/Winter 2001 edition) we considered the implications of working with labile compounds, specifically as they affect bioanalysts and their ‘customers’. In this part of the article, we turn to practical measures that can be adopted to eliminate these effects, or at least to reduce them to levels at which they do not impact upon the integrity of bioanalytical data. The choice of which of the following measures to adopt depends upon a knowledge of the likely mechanism for the observed instability.
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