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Validated Methods

Validated Bioanalytical Assays

We have a wide range of clinical and preclinical non-proprietary methods which are validated to current regulatory guidelines.  If a compound of interest is not listed, please contact us as we have vast experience in the development and validation of small and large molecules and we will usually be able to support your bioanalytical project at short notice.

 Our range of state-of-the-art instrumentation and technologies includes:

  • Waters Xevo™ TQ-S LC-MS/MS systems
  • AB SCIEX API 4000™ and 5000™ LC-MS/MS systems
  • Waters Acquity I-Class UPLC™ and Shimadzu Nexera UHPLC systems
  • Hamilton MicroLab Star robotics systems
  • Spark-Holland Symbiosis™ Pharma systems
  • Immunoassay
  • GyroLab and MSD systems
  • Watson LIMS and Labnotes ELN

Validated Bioanalytical Methods

Compound 

LLOQ 

ULOQ 

Species & Matrix 

Type 

1-Hydroxymidazolam  0.1 ng/mL 100 ng/mL   Human Plasma                LC-MS/MS
4'-Hydroxyflurbiprofen 0.25 µg/mL    25 µg/mL  Human Urine   LC-MS/MS  
4-Hydroxytolbutamide  10 ng/mL  5,000 ng/mL    Human Plasma   LC-MS/MS
5-Aminosalicylic Acid (ASA)   5.0 µg/mL 1,000 µg/mL  Human Urine   LC-MS/MS
5-Aminosalicylic Acid (ASA) 5.0 ng/mL 5,000 ng/mL  Human Plasma  LC-MS/MS
5-Hydroxyomeprazole 5.0 ng/mL 2,000 ng/mL  Human Plasma  LC-MS/MS
6ß-Hydroxycortisol 200 ng/mL 35,000 ng/mL  Human Urine   LC-MS/MS
7-Hydroxymethotrexate 5.0 ng/mL 1,000 ng/mL   Human Plasma    LC-MS/MS
7-Hydroxymethotrexate 20 ng/mL 15,000 ng/mL   Human Urine   LC-MS/MS
9-Hydroxyrisperidone 0.1 ng/mL 100 ng/mL  Human Plasma   LC-MS/MS
17-Hydroxyexemestane 50 pg/mL 5,000 pg/mL   Human Plasma   LC-MS/MS
24,25-Dihydroxycholecalaciferol  50 pg/mL  10,000 pg/mL   Human Plasma   LC-MS/MS
Adefovir  0.5 ng/mL  500 ng/mL  Human Plasma   LC-MS/MS
Amoxicillin  100 ng/mL  20,000 ng/mL  Human Plasma   LC-MS/MS
Buprenorphine 1.0 pg/mL  1, 000 pg/mL  Human Plasma   LC-MS/MS
Caffeine 20 ng/mL 5,000 ng/mL   Human Plasma   LC-MS/MS
Calcifediol 1.0 ng/mL  200 ng/mL   Human Plasma   LC-MS/MS
Calcitriol 10 pg/mL 2,000 pg/mL  Human Plasma  LC-MS/MS
Candesartan 0.5 ng/mL 250 ng/mL  Human Plasma  LC-MS/MS
Ciprofloxacin  5.0 ng/mL  5,000 ng/mL  Human Plasma  LC-MS/MS
Clopidogrel carboxylic acid  5.0 ng/mL  5,000 ng/mL  Human Plasma  LC-MS/MS
Cortisol  5.0 ng/mL 5,000 ng/mL   Human Plasma  LC-MS/MS
Cortisol 40 ng/mL  7,000 ng/mL   Human Urine  LC-MS/MS
C-Reactive Protein (CRP) 1.0 ng/mL 100 ng/mL  Human Plasma  ELISA
Cyclosporin 20 ng/mL  4,000 ng/mL  Human Whole Blood  LC-MS/MS
Dextromethorphan 10 ng/mL  2,000 ng/mL  Human Urine  LC-MS/MS
Dextrorphan 100 ng/mL 20,000 ng/mL   Human Urine  LC-MS/MS
Digoxin 0.1 ng/mL 5.0 ng/mL  Human Plasma  LC-MS/MS
Dihydrotestosterone 100 pg/mL  5,000 ng/mL  Human Serum  LC-MS/MS
Diltiazem  1.0 ng/mL  250 ng/mL   Human Plasma  LC-MS/MS
Docetaxel  0.5 ng/mL  1,000 ng/mL   Human Plasma  LC-MS/MS
Exemestane  0.1 ng/mL  25 ng/mL   Human Plasma  LC-MS/MS
Flurbiprofen  0.1 µg/mL 20 µg/mL   Human Plasma  LC-MS/MS
Flurbiprofen   0.25 µg/mL   25 µg/mL  Human Urine  LC-MS/MS
Fluticasone Propionate  1.0 pg/mL  200 pg/mL   Human Plasma  LC-MS/MS
Glibenclamide  2.0 ng/mL  1,000 ng/mL   Human Plasma  LC-MS/MS
Glipizide  5.0 ng/mL  2,000 ng/mL   Human Plasma  LC-MS/MS
Hydroxyitraconazole  1.0 ng/mL  1,000 ng/mL  Human Plasma  LC-MS/MS
Hydroxymetronidazole  100 ng/mL  10,000 ng/mL   Human Plasma  LC-MS/MS
Itraconazole  1.0 ng/mL  1,000 ng/mL   Human Plasma  LC-MS/MS
Ketoconazole 10 ng/mL  5,000 ng/mL   Human Plasma  LC-MS/MS
Lamivudine  2.0 ng/mL  2,000 ng/mL   Human Plasma   LC-MS/MS
Lorazepam  1.0 ng/mL  150 ng/mL   Human Plasma   LC-MS/MS
Metformin  20 ng/mL  5,000 ng/mL   Human Plasma  LC-MS/MS
Methotrexate  5.0 ng/mL  1,000 ng/mL   Human Plasma   LC-MS/MS
Methotrexate  50 ng/mL 1,000 ng/mL   Human Urine   LC-MS/MS
Metronidazole  500 ng/mL  30,000 ng/mL   Human Plasma   LC-MS/MS
Midazolam 0.1 ng/mL  100 ng/mL   Human Plasma   LC-MS/MS
Moxifloxacin  50 ng/mL  7,500 ng/mL   Human Plasma   LC-MS/MS
N-Acetyl-5-Aminosalicylic Acid (NASA)  5.0 ng/mL  5,000 ng/mL   Human Plasma   LC-MS/MS
N-Acetyl-5-Aminosalicylic Acid (NASA)  5.0 µg/mL 5,000 µg/mL  Human Urine   LC-MS/MS
Norbuprenorphine 5.0 pg/mL 1,000 pg/mL   Human Plasma   LC-MS/MS 
O-Desmethyl Venlafaxine  1.0 ng/mL  400 ng/mL   Human Plasma   LC-MS/MS
Omeprazole 5.0 ng/mL  2,000 ng/mL   Human Plasma   LC-MS/MS
Omeprazole Sulphone 5.0 ng/mL  2,000 ng/mL   Human Plasma   LC-MS/MS
Paraxanthine  20 ng/mL  5,000 ng/mL   Human Plasma   LC-MS/MS
Pioglitazone  25 ng/mL  5,000 ng/mL   Human Plasma  LC-MS/MS
Pioglitazone MIV  25 ng/mL  5,000 ng/mL   Human Plasma  LC-MS/MS
Pravastatin  0.1 ng/mL  100 ng/mL   Human Plasma   LC-MS/MS
Prednisolone  0.5 ng/mL  500 ng/mL   Human Plasma   LC-MS/MS
Prednisolone  20 ng/mL  20,000 ng/mL   Human Plasma  LC-MS/MS
Risperidone  0.1 ng/mL 100 ng/mL   Human Plasma  LC-MS/MS
Salbutamol  50 pg/mL  10,000 pg/mL   Human Plasma  LC-MS/MS
Salbutamol 3.0 ng/mL  1,000 ng/mL   Human Urine  LC-MS/MS
Salmeterol 5.0 pg/mL  1,000 pg/mL   Human Plasma  LC-MS/MS
Salmeterol 1.0 pg/mL  200 pg/mL  Human Plasma  LC-MS/MS
Simvastatin  0.05 ng/mL  100 ng/mL   Human Plasma  LC-MS/MS
Simvastatin Acid  0.05 ng/mL  100 ng/mL   Human Plasma  LC-MS/MS
Sitagliptin  5.0 nM  5000 nM   Human Plasma  LC-MS/MS
Sulfamethoxazole  1.0 µg/mL 100 µg/mL   Human Plasma  LC-MS/MS
Testosterone  250 pg/mL 50,000 pg/mL
 Human Serum  LC-MS/MS
Testosterone 50 pg/mL 25,000 pg/mL   Human Serum  LC-MS/MS
Tolbutamide 10 ng/mL 5,000 ng/mL  Human Plasma  LC-MS/MS
Venlafaxine  1.0 ng/mL  400 ng/mL   Human Plasma  LC-MS/MS
Warfarin (R & S)  20 ng/mL  5,000 ng/mL  Human Plasma   LC-MS/MS

For further information on our validated methods and to discuss your specific requirements please contact us on +44 (0) 1904 686060 or email info@yorkbio.com

 

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